PERAN AIR REBUSAN DAUN SALAM (SYZGIUM POLYANTHUM) DALAM MENURUNKAN KADAR ASAM URAT

  • Miftafu Darussalam Stikes Jenderal Achmad Yani Yogyakarta
  • Dwi Kartika Rukmi Stikes Jenderal Achmad Yani Yogyakarta
DOI: https://doi.org/10.30989/mik.v5i2.149

Abstract

Background: Uric acid is a final product or a waste that is resulted from the metabolism of purines. A high level of uric acid (hyperuricemia) will cause several health problems, such as vascular inflammation, smooth muscle proliferation, and vascular lesion in kidneys. The syzygium polyanthum leaves contain bioactive substances that may affect the level of uric acid in blood.

Objective: This study aimed to determine the influence of boiled water of syzygium polyanthum leaves to the changes of uric acid levels in the target area of Puskesmas Pandak 1 Bantul.

Methods: This study employed pre- and post-test without control group design. The population consisted of all patients with hyperuricemia in the target area of Puskesmas Pandak 1 Bantul. Sample was selected with a concecutive sampling, gaining a total number of 24 respondents. Data were analyzed with the Wilcoxon test. The dose of boiled water of syzygium polyanthum leaves intake was 0.36g/ KgBW, once a day for 14 days.

Result: This research showed that the boiled water of syzygium polyanthum leaves decreased hyperuricemia (uric acid levels), along with the significancy value of 0.009 (p <0.05). At the pre-test time, the average level of uric acid reached 7.279 mg/dl, and after the treatment, it decreased to 6.76 mg/dl.

Conclusion: This study has established evidence that the boiled water of syzygium polyanthum leaves is able to decrease hyperuricemia (uric acid level in blood).

Keywords: Syzygium polyanthum, boiled water of syzygium polyanthum leaves, hyperuricemia

Author Biographies

Miftafu Darussalam, Stikes Jenderal Achmad Yani Yogyakarta

Jl. Ringroad Barat Ambarketawang Gamping Sleman Yogyakarta 0274 434 2000

Dwi Kartika Rukmi, Stikes Jenderal Achmad Yani Yogyakarta

Jl. Ringroad Barat Ambarketawang Gamping Sleman Yogyakarta 0274 434 2000

References

1. Berry CE and JM Hare. Xanthine Oxidoreductase and Cardiovascular Disease: Molecular Mechanism and Pathophysiological Implications. Am J Physiol, 2004. pp: 589-606.
2. Hediger MA, Johnson RJ, Miyazaki H, Endou H. Molecular Physiology of Urate Transport. Am J Physiol. 2005. pp: 125- 33.
3. Putra,T.R. Hiperurisemia. In: Sudoyo dkk (ed). Buku Ajar Ilmu Peyakit Dalam Jilid II Edisi IV. Jakarta: 2006. FKUI, pp: 1213- 17.
4. Nan H, Qing Qiao, Yanhu Dong, Weiguo Gao, Bin Tang, Rongli Qian. The prevalence of hyperuricemia in a population of the Coastal City of Qingdao, China. J Rheumatol 2006 ;33:1346-50.
5. Indrawan IGNB. Hubungan Konsumsi Purin Tinggi dengan Hiperurisemia Studi Potong Lintang Analitik pada Penduduk Suku Bali di Kota Denpasar.Denpasar: In Press. 2005.
6. Heinig M and RJ Johnson. Role of Uric Acid in Hypertension, Renal Disease, and Metabolic Syndrome. Cleveland Clinic Journal of Medicine, 2006. pp: 1059-64.
7. Feig DI, Kang DH, Johnson RJ. Uric Acid and Cardiovascular Risk. N Eng J Med, 2008. pp: 1811-21.
8. Muhtadi, Suhendi. A, Nurcahyanti. W. & Sutrisna, E.M. Potensi daun salam (syzigium polyanthum walp.) dan biji jinten hitam (nigella sativa linn) sebagai kandidat obat herbal terstandar asam urat. 2012. Pharmacon,vol.13 no 1.
9. Wijayakusuma, H. Tumbuhan Berkhasiat Obat Indonesia Rempah, Rimpang dan Umbi. Prestasi Instan Indonesia, Jakarta. 2002.
10. Abdibiof. Penyusunan Pedoman Bahan Saintifikasi Jamu. 2012. Didownload di Pada tanggal 23 Mei 2014.
11. Badan Pengawas Obat dan Makanan. Kandungan kimia sembilan tanaman obat unggulan. 2004. Didownload di , pada tanggal 23 Mei 2014.
12. Pidrayanti, L.T.M. Pengaruh Pemberian Ekstrak Daun Salam (Eugenia Polyantha) Terhadap Kadar Ldl Kolesterol Serum Tikus Jantan Galur Wistar Hiperlipidemia. Semarang : 2008. karya tulis ilmiah fakultas kedokteran Universitas Diponegoro, Semarang (tidak dipublikasikan).
13. Handadari, H. R. Efek Decocta Daun Salam (Eugenia polyantha Wight.) Terhadap Penurunan Kadar Asam Urat dalam Darah Mencit Putih (Mus muculus) Jantan hiperurisemia, Skripsi, Fakultas Farmasi Universitas Muhammadiyah Surakarta, Surakarta. 2007.
14. Ngestiningsih, D., Widiastuti, I.,Wahyu,T.,Hadi,S., & Suntoko,B. Perbedaan Pemberian Ekstrak Herbal (Daun Salam, Jintan Hitam, Dan Daun Seledri) Dengan Allopurinol Terhadap Kadar Il-6 Dan Tnf-Α Serumpenderita Hiperurisemia. 2012. Medica hospitalia. Vol.1.,No.1 Mei 2012.
15. Ariyanti, R. Pengaruh Pemberian Infusa Daun Salam (Eugenia polyantha Wight.)Terhadap Penurunan Kadar Asam Urat dalam Darah Mencit Putih Jantan hiperurisemia, Skripsi, Fakultas Farmasi Universitas Muhammadiyah Surakarta, Surakarta. 2007.
16. Putra, Tjokorda Raka. Hiperurisemia. In: Sudoyo dkk (ed). Buku Ajar Ilmu Peyakit Dalam Jilid II Edisi IV. Jakarta: FKUI, 2006. pp: 1213-17.
17. Becker & Menaaskshi. Clinical gout dan pathogenesis of hyperuricemia. Arthritis and allied condition, A textbook of rheumatology. 2005. 13 ed vol.2 editor WJ koopman, Baltimore: William & Wilkin Company,2303-39
18. Pangaribuan, E.M., Sudharmono, U. & Rantung, G.A.J. 2013. Uji Penggunaan Daun Salam (Syzygium Polyanthum) Untuk Menurunkan Kadar Kolesterol Pada Laki-Laki Usia 45-65 Tahun. Bandung : Prosiding Seminar Kontribusi Fisika 2013 ISBN 978-602-19655-5-9.
19. Muflikhatur S.R. dan Murwani, H.R. Perbedaan Pengaruh Antara Ekstrak dan Rebusan Daun Salam (Eugenia polyantha) Dalam Pencegahan Peningkatan Kadar Kolesterol Total Pada Tikus Spraque Dawley. Journal of Nutrion. 2014. College. 3(1): 148.
Published
2019-11-09
How to Cite
1.
Darussalam M, Kartika Rukmi D. PERAN AIR REBUSAN DAUN SALAM (SYZGIUM POLYANTHUM) DALAM MENURUNKAN KADAR ASAM URAT. Media ilmu kesehatan [Internet]. 2019Nov.9 [cited 2024Nov.19];5(2):83-1. Available from: https://ejournal.unjaya.ac.id/index.php/mik/article/view/149
Issue
Vol 5 No 2 (2016): Media Ilmu Kesehatan
Section
Articles

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