Deteksi Varian Rhesus Dweak pada Populasi Rhesus Negatif di Provinsi DKI Jakarta
DOI:
https://doi.org/10.30989/mik.v11i2.744Keywords:
Detection, Rhesus, VariantAbstract
Background: The Rhesus blood group system is determined by the presence or absence of the D-antigen, and has clinical importance because it can cause Haemolytic Transfusion Reaction (HTR) and Haemolytic Disease of the Newborn (HDN). There are several variants of the D-antigen which are weak, so it will be detected as Rhesus Negative.
Objective: The purpose of this study was to determine the prevalence of the Rhesus D weak blood group variant in DKI Jakarta Province, so that it could determine the identity status of the blood group correctly.
Methods: The samples used in this study were whole blood samples with a maximum storage time of three days in the blood refrigerator. The examination used in this study is the Indirect Antiglobulin Test (IAT).
Results: Rhesus Dweak variant was detected in 103 samples examined using the IAT examination method.
Conclusion: Determination of the Rhesus variant in individuals is necessary to prevent clinical impact on the patient. Further examination is needed to ensure the D-antigen of the Rhesus blood group
References
Primer of Blood Administration, AABB, Chapter 1, page 3-7, Rev.2012.
Daniels G, Human Blood Groups, Second edition, Blackwell Science Ltd, Australia, 2002, Chapter 1
Castillo B, Dasgupta A, Klein K, Tint H, Wahed A, Transfusion Medicine for Pathologist : A Comprehensive Review for Board Preparation, Certification and Clinical Practise, First Edition, 2018, DOI : 10.1016/b978-0-12-814313-1.00005-8
Dean L, Blood Group And Red Cell, National Centre for Biotechnology Information (NCBI), USA, 2005, Chapter 7. The Rh Blood Group
Choate J.D, Clinical Principles of Transfusion Medicine : ABO and Rh Blood Groups, Elsevier, 2018, pp. 15–24. https://doi.org/10.1016/B978-0-323-54458-0.00003-9
Huang CH, Rh Factor and Rh System, Brenner’s Encyclopedia of Genetics 2nd Edition, Vol 6, Elsevier, New York Blood Centre, New York, USA, 2013, https://doi.org/10.1016/B978-0-12- 374984-0.01333-4
Daniels G, Variants of RhD – Current testing and clinical consequences, British Jurnal of Haematology, UK, 2013, https://doi:10.1111/bjh.12275
Westhoff CM, The Stucture and Function of The Rh Antigen Complex, Seminar in Hematology, Elsevier, 2007, American Red Cross and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, https://doi.org/10.1053/j.seminhematol.2006.09.010
Avent MD, Reid ME, The Rh Blood Group System : A Review, Blood, volume 95, number 2, New York, 2000, https://doi.org/10.1182/blood.V95.2.375
Sandler S.G, Flegel W.A, Westhoff C.M, Denomme G.A, Delaney M, Keller M.A, et.all, Transfusion Medicine and Hemostasis : Rh and RhAG Blood Group Systems, Elsevier, 2019, pp. 149–155. https://doi.org/10.1016/B978-0-12-813726-0.00026-X
Infodatin : Pusat Data dan Informasi, Kementerian Kesehatan RI, Pelayanan Darah di Indonesia, 2016.
Harmening DM, Modern Blood Banking and Transfusion Practices, 5th ed, Philadelphia, PA: F.A, Davis Company, 2005.
Li, Q., Hou, L., Guo, Z.-H., Ye, L.-Y., Yue, D.-Q., & Zhu, Z.-Y. (2009). Molecular basis of the RHD gene in blood donors with DEL phenotypes in Shanghai. Vox Sanguinis, 97(2), 139–46. doi:10.1111/j.1423- 0410.2009.01181.x
Sandler SG, Chen L, Flegel WA, Serological weak D phenotypes : A review and guidance for interpreting the RhD blood type using the RHD genotype, Br J Haematol, Department of Health and Human Services, USA, 2017, available in PMC 2018, doi : 10.1111/bjh.14757
Westhoff CM, Molecular DNA–Based Blood Group Typing, Transfusion Medicine and Hemostasis, Elsevier, 2019, https://doi:10.1016/b978-0-12-813726-0.00024-6
Körmöczi GF, Gassner C, Shao CP, Uchikawa M, Legler TJ, Immunohematology : A comprehensive of DEL types : partial DEL individuals are prone to anti-D alloimmunization, Transfusion, vol.45, October 2005
Rizzo C, Castiglia L, Arena E, Gangi S, Mazzola G, Carusso C, Vasto S, Weak D and partial D: our experience in daily activity, Blood Transfus, University Hospital, Palermo, Italy, 2012, https://doi.org/10.2450/2012.0060-11
Peraturan Menteri Kesehatan RI Nomor 91 tentang Standar Pelayanan Transfusi Darah, 2015.
Wah TS, Chi SN, Kyaing KK, Khin AA, Aung T, Serological Detection of Rh-DEL Phenotype Among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar, Hindawi, 2020
Wagner T, Körmöczi GF, Buchta C, Vadon M, Lanzer G, Mayr WR, et al. Anti-D immunization by DEL red blood cells, Transfusion 2005; 45:520-6
Zarandona JM and Yazer MH, The role of the Coombs test in the evaluation of hemolysis in adults, Canadian Medical Association Journal, 2006, DOI: 10.1503/cmaj.051489
Downloads
Published
How to Cite
Issue
Section
License
Articles received and published by the Media Ilmu Kesehatan are by the publication, the copyright of the article is fully transferred to the Media Ilmu Kesehatan. All operational forms such as printing, publication, and distribution of hard file journals are carried out by the Media Ilmu Kesehatan. Articles that have finished the review process and have been declared accepted by the journal manager or editor will be asked to fill out a statement of submission of copyright by the journal secretary to the main author or correspondent author. The statement of transfer of copyright is signed with a seal and sent via email to journalmik2018@gmail.com and contacted the admin of the journal to be followed up on archiving. Journal managers and editors have the right to edit the manuscript according to the provisions of the writing rules in the Media Ilmu Kesehatan.
Articles that have been declared accepted either online through the author's account on the OJS website https://ejournal.unjaya.ac.id/index.php/mik or a letter of receipt of the article (LOA), as well as those that have been published on OJS are not allowed to be published in other journals, or proceedings. The number of authors with more than one and as the main author or designated as the correspondent writer must have coordinated with members of the research team. The order of the authors submitted in the article as the author of one, two, three and so on cannot be changed when the article is published unless an error occurs in the technical operation of the journal.