Deteksi Antibody Anti-Human Leukocyte Antigen (HLA) Kelas I Pada Donor Darah Wanita
Abstract
Background: HLA class I is very polymorphic, if it enters the body of another person it will be considered foreign so that alloimmunization can occur by producing class I anti-HLA antibodies. These antibodies are found in individuals exposed to allogeneic cells due to transfusion, problems, and pregnancy. Female blood donors who have anti-HLA class I antibodies when donating blood and transfused to patients who have the appropriate HLA can cause a transfusion reaction. Research on class I anti-HLA antibodies in female blood donors in Indonesia is still very rare. This research is further to get an overview of class I anti-HLA antibodies in female blood donors.
Objective: To determine the presence of potential class I anti-HLA antibodies in female donors.
Methods: The subjects of this study were 30 female donors who had never been pregnant and 60 donors who had been pregnant and gave birth who donated their blood at UTD PMI DKI Jakarta. The collected samples were screened using the whole platelet ELISA method to detect platelet antibodies, namely anti-HPA and anti-HLA class I antibodies, followed by consulting anti-HLA class I antibodies with the MAIPA method.
Results: Sixteen samples were detected to contain anti-platelet antibodies and 74 were negative. Identification of class I anti-HLA antibodies in 16 samples showed all negative results.
Conclusion: Identification of 16 positive anti-platelet antibody samples in female donors did not show class I anti-HLA antibodies
References
Abbas AK, Lichtman AH, Pillai. S. Basic Immunology Functions and Disorders the Immune system. 5th ed. St. Louis: Elsevier; 2014.
Dahl J. Maternal Anti-HLA Class I Antibodies in Connection with Pregnancy and Neonatal Thrombocytopenia – A Cause for Concern? UiT. University Of Norway; 2017.
Lee J, Romero R, Xu Y, Miranda J, Yoo W, Chaemsaithong P, Kusanovic JP, Chaiworapongsa T, Tarca AL, Korzeniewski SJN Hassan SS, Gabor T KC. Detection of anti-HLA antibodies in maternal blood in the second trimester to identify patients at risk for antibody-mediated maternal anti-fetal rejection and spontaneous preterm delivery. NIH Public Access. 2013;70(2):162–75.
Jeremiah ZA, Oburu JE, Buseri FI, Harcourt P. Alloantibodies to HLA Class 1 Antigens Detected in Multiparous Women of African Descent Are Significantly Associated with Age , ABO / Rh Blood Groups and Parity. Am J Biomed Sci. 2010;2(3):289–94.
Weinstock C, Schnaidt M. Human Leucocyte Antigen Sensitisation and Its Impact on Transfusion Practice. Transfus Med Hemotherapy. 2019;46(5):356–68.
De Clippel D, Baeten M, Torfs A, Emonds MP, Feys HB, Compernolle V, et al. Screening for HLA antibodies in plateletpheresis donors with a history of transfusion or pregnancy. Transfusion. 2014;54(12):3036–42.
Imoto S, Kawamura K, Tokumine Y, Araki N, Akita S, Nishimura C, et al. Acute non-hemolytic transfusion reactions and HLA class I antibody : advantages of solid phase assay compared with conventional complement-dependent assay. 2019;95–103.
Peters AL, Van Stein D, Vlaar APJ. Antibody-mediated transfusion-related acute lung injury; from discovery to prevention. Br J Haematol. 2015;170(5):597–614.
Association Bulletin #14-02. TRALI Risk Mitigation for Plasma and Whole Blood for Allogeneic Transfusion. AABB [Internet]. 2014; Available from: https://www.aabb.org/programs/publications/bulletins/documents/ab14-02.pdf
Otrock ZK, Liu C, Grossman BJ. Transfusion-related acute lung injury risk mitigation : an update. VoxSanguin. 2017;694–703.
UTD PMI PUSAT. Laporan Tahunan UTD PMI Pusat Jakarta.pdf. Jakarta: UTD PMI Pusat; 2019.
Ritchie NK. Antibodi Anti-HLA Kelas 1 pada Serum Resipien Transfusi Darah Berulang sebagai Penyebab Inkompatibilitas Trombosit Pre-Transfusi. 2015.
Curtis BR, Mcfarland JG. Human platelet antigens - 2013. Vox Sang. 2014;106(2):93–102.
Fung MK, Grossman BJ, Hillyer CD, Wethoff. CM. AABB Technical manual. 19, editor. 2014. 243–244 p.
Denise M. Harmening. Modern Blood Banking and Transfusion Practices. 5th ed. Philadelphia; 2001.
Heikal NM, Smock KJ. Laboratory testing for platelet antibodies. Am J Hematol. 2013;88(9):818–21.
Kaplan C, Freedman J, Foxcroft Z, Husebekk A, Metcalfe P, Muniz-Diaz E, Ouwehand W, Panzer S, Rozman P SB. Monoclonal platelet antigen capture assays (MAIPA) and reagents: A statement. Vox Sang. 2007;93(4):298–9.
Curtis BR. Practical Transfusion Medicine; Platelet and Neutrophil Antigens. 5th ed. Practical Transfusion Medicine. John Wiley & Sons Ltd; 2017. 43–52 p.
Triulzi DJ, Kleinman S, Kakaiya RM, Busch MP, Norris PJ, Steele WR, et al. The Effect of Previous Pregnancy and Transfusion on HLA Alloimmunization in Blood Donors: Implications for a Transfusion Related Acute Lung Injury (TRALI) Risk Reduction Strategy. NIH Public Access. 2010;49(9):1825–35.
Powers A, Stowell CP, Dzik WH, Saidman SL, Lee H, Makar RS. Testing only donors with a prior history of pregnancy or transfusion is a logical and cost-effective transfusion-related acute lung injury prevention strategy. Transfusion. 2008;48(12):2549–58.
Kampen CA V, Maarschalk MFVV, Langerak-Langerak J, Roelen DL, Claas FHJ. Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child. Hum Immunol. 2002;63(6):452–8.
Kampen CA V, Maarschalk MFJVDV, Langerak-langerak J, Beelen E Van, Roelen DL, Claas FHJ. Pregnancy Can Induce Long-Persisting Primed CTLs Specific for Inherited Paternal HLA Antigens. 2001;8859(01).
Schnaidt M, Wernet D. Platelet-specific antibodies in female blood donors after pregnancy. Transfus Med. 2000;10(1):77–80.
Kiefel V, Santoso S, Weisheit M et al. Monoclonal antibody-specific immo- bilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies Kiefel V, Santoso S, Weisheit M, et al. Monoclonal antibody-specific immo- bilization of platelet antigens (MAIPA. 1987;
Yang WH, Cheng CS, Chang JB, Liu KT, Chang JL. Antibody formation in pregnant women with maternal-neonatal human platelet antigen mismatch from a hospital in northern Taiwan. Kaohsiung J Med Sci [Internet]. 2014;30(1):25–8. Available from: http://dx.doi.org/10.1016/j.kjms.2013.07.005
Wang E, Adams S, Marincola FM, Stroncek DF. Blood Banking And Transfusion Medicine. Human Leukocyte and Granulocyte Antigens and Antibodies: The HLA and HNA Systems. second edi. 2007. 129–156 p.
Jeremiah ZA, Atiegoba AI, Mgbere O. Alloantibodies to human platelet glycoprotein antigens (HPA) and HLA class 1 in a cross section of Nigerian antenatal women. Hum Antibodies. 2011;20(3–4):71–5.
Nelson JL. The otherness of self: Microchimerism in health and disease. Trends Immunol. 2012;33(8):421–7.
Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, et al. Microchimerism of maternal origin persists into adult life. J Clin Invest. 1999;104(1):41–7.
Suciu-Foca N, Reed E, Rohowsky C, Kung P, King DW. Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy. Proc Natl Acad Sci U S A. 1983;80(3 I):830–4.
Dankers MKA, Roelen DL, Korfage N, De Lange P, Witvliet M, Sandkuijl L, et al. Differential immunogenicity of paternal HLA class I antigens in pregnant women. Hum Immunol. 2003;64(6):600–6.
Ihtesham A, Maqbool S, Nadeem M, Janjua MBA, Sundus O, Naqqash AB, et al. Helicobacter pylori induced immune thrombocytopenic purpura and perspective role of helicobacter pylori eradication therapy for treating immune thrombocytopenic purpura. AIMS Microbiol. 2021;7(3):284–303.
Ercolini AM, Miller SD. The role of infections in autoimmune disease. Clin Exp Immunol. 2009;155(1):1–15.
Hasni SA. Role of helicobacter pylori infection in autoimmune diseases. Curr Opin Rheumatol. 2012;24(4):429–34.
Syam AF, Miftahussurur M, Makmun D, Nusi IA, Zain LH, Zulkhairi, et al. Risk factors and prevalence of Helicobacter pylori in five largest islands of Indonesia: A preliminary study. PLoS One. 2015;10(11):1–14.
Cines DB, Bussel JB, Liebman HA, Luning Prak ET. The ITP syndrome: Pathogenic and clinical diversity. Blood. 2009;113(26):6511–21.
Al-Samkari H, Leaf RK, Goodarzi K. Transient Thrombocytopenia With Glycoprotein-Specific Platelet Autoantibodies After Ad26.COV2.S Vaccination: A Case Report. Ann Intern Med. 2021;174(11):1632–3.
Bhattacharjee S, Banerjee M. Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review. SN Compr Clin Med. 2020;2(11):2048–58.
Xu P, Zhou Q, Xu J. Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol. 2020;99(6):1205–8.
Deruelle E, Ben Hadj Salem O, Sep Hieng S, Pichereau C, Outin H, Jamme M. Immune thrombocytopenia in a patient with COVID-19. Int J Hematol [Internet]. 2020;112(6):883–8. Available from: https://doi.org/10.1007/s12185-020-02943-5
Bomhof G, Mutsaers PGNJ, Leebeek FWG, te Boekhorst PAW, Hofland J, Croles FN, et al. COVID-19-associated immune thrombocytopenia. Br J Haematol. 2020;190(2):e61–4.
Ashraf S, Alsharedi M. COVID-19 induced immune thrombocytopenic purpura: case report. Stem Cell Investig. 2021;8:14–14.
Johnsen J. Pathogenesis in immune thrombocytopenia : new insights [Internet]. American Society of Hematology; 2012. 306–312 p. Available from: https://sci-hub.wf/10.1182/asheducation-2012.1.306
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