Potensi ekstrak daun pare (momordica charantia l.) sebagai alternatif meningkatkan kualitas hidup penderita Hepatitis B
Abstract
Background: Hepatitis is a desease that can be transmitted through blood transfussion. Treatment for this infectious desease can be done with antibotics or chemotherapy. The use of other herbal can also minimize the negative impact of using chemical products. The research needs to be used as hepatitis drugs. According to previous research it was stated that pare (Momordica charantia L.) leaves showed hepatoprotective ability.
Objective: to determine the potential of bitter melon leaf extract (Momordica charantia L.) in treating hepatitis B.
Methods: This study is used completely randomized design with three treatments. Each of the six replications was treated as follows, normal control, positif control (giving parasetamol dosis 750 mg/kg BB rats. Giving extract pare leaves (dosis 100 mg/kg BB rats).
Results: The results of the one-way ANOVA test (Oneway Anova) SGOT and SGPT showed that there was a very significant effect between the treatment of bitter melon leaf extract on the levels of SGOT in rats with a significance value of 0.000.
Conclusion: The observation parameters are measurement of leaves SGOT and SGPT. The results showed that pare leaf extract has the potential as a hepatoprotector. It isi hoped that this research can provide information add insight into science to utilize plants as herbal medicine.
References
Cahyono, J.B.S.B. Hepatitis B cegah kanker hati. Kanisius : Yogyakarta.2010.
Ahmad I., Beg, A.Z. Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogen. J Ethnopharmacol. 74: 113-123.
Nascimento G.G.F., Locatelli J., Freitas P.C. and Silva G.L. 2010. Antibacterial activity of plant extracts and phytochemical on antibiotic resistant bacteria. Braz J Microbiol. 2001. 31: 247-256.
Barnum SR. Biotechnology: An Introduction. USA: Wadsworth Publishing Company. 1998.
Cannell, R. How to approach the isolation of natural product. Springer. 1998. 4, pp. 1-51.
Lovly, M.S. Merlee. In vitro bioactivity and phytochemical characterazation of Nypa fruticant Wurmb. International research journal of biological sciences. 2017. 6(6). 42-52
Sethi, Poonam. Momordica charantia L-an ethnobotanical drug. International journal of pharma and bio sciences. 2012. Vol 3(2).
Yang Lin Yeo. Yin Y.C., Chin, H.L., Heng, S.S. Wai,S.Y. Effectivitas of maceration periods with deifferent extraction solvent on in vitro antimicrobial activity from fruits of Momordica charantia L. Journal of AO./;pplied Pharmaceutical Science. 2014. Vol. 4 (10), pp. 016-023,
Subratty A.H, Fakim A.G., and Mahomoodally F. Bitter melon: an exotic vegetable with medicinal values. Nutrition and Food Science. 2005. 35(3): 143–147.
Wulan, Dewi Retno. Pengaruh Ekstrak Buah Pare (Momordica Charantia L) Terhadap Histopatology Sel Hepar Pada Tikus Putih (Rattus Novergicus Strain Wistar) Yang Telah Diinduksi Alkohol. Fakultas Kedokteran Universitas Muhammadiyah Malang. 2015.
Ghozali, M.T., Puguh, N.A. Uji hepatoprotektor teh hijau kombucha pada tikus putih yang diinduksi parasetamol. Jurnal ilmiah farmasi. Vol.9 No. 2 Tahun 2012.
Hikmah,N.E. Penggunaan obat-obatan penginduksi penyakit hati terhadap pasien gangguan fungsi hati di rumah sakit x surakarta tahun 2013. Fakultas farmasi, universitas muhammadiyah surakarta. 2014..
Rafita, I.D.,Lisdiana., Aditya, M. pengaruh ekstrak kayu manis terhadap gambaran histopatologi dan kadar SGOT-SGPT hepar tikus yang diinduksi parasetamol. Unnes Journal of Life Science. 2015. 4 (1) 29-37 29.
Soemantri, Julia Setyadi Ag. Transfusi darah yang rasional. Pelita Insani: Semarang. 2010.
Ardiaria, Martha. Pengaruh Vitamin E Terhadap Kadar SGOT dan SGPT pada Tikus yang Diberi Parasetamol. JNH(Journal of Nutrition and Health). 2017. Vol.5 No.2
Anilakumar, Kandangath R., Garlapati, P.K., Nallamuthu I. Nutritional, Pharmacological and medical properties of Momordica charantia. International Journal of Nutrition and Food Sciences. 2015. 4(1): 75-83
Indahsari, Noer Kumala. Histopatologi hepar tikus putih (Rattus novergicus) yang diinduksi dengan parasetamol dosis toksik pasca pemberian ekstrak etanol daun kelor (Moringa oleifera). Jurnal Kimia Riset, 2017. Volume 2 No. 2. 123 - 130
Kobori M, Nakayama H, Fukushima K, Ohnishi-Kameyama M, Ono H, Fukushima T, Akimoto Y, Masumoto S, Yukizaki C, Hoshi Y, Deguchi T, Yoshida M. Bitter gourd suppresses lipopolysaccharide-induced inflammatory responses. J. Agric. Food Chem., 2008. 56: 4004-4011.
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