Efektivitas rimpang kunyit hitam (curcuma caesia roxb.) terhadap penurunan glukosa darah dan perbaikan ginjal tikus diabetes nefropati

  • Zakiyyah Qurrotul Aini Universitas Setia Budi
  • Wiwin Herdwiani Universitas Setia Budi
  • Tri Wijayanti Universitas Setia Budi

Abstract

Background: Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Diabetic nephropathy is a degenerative kidney vascular disorder that has a relationship with impaired carbohydrate metabolism or sugar intolerance (Diabetes Mellitus). Black turmeric (Curcuma Caesia Roxb.) is widely used by the community as a traditional medicine and has potential as an antidiabetic.
Objective: This study aims to determine the effect of black turmeric extract on decreasing blood glucose levels and its effect on improving kidney histopathology in diabetic nephropathy rats.
Method: This research was conducted at the Laboratory of the Center for Food and Nutrition Studies, University of Gajah Mada for the period October-November 2022 consisting of 6 groups. STZ-Na induced rats to obtain a state of hyperglycemia. Examination of blood glucose levels using the GOD-PAP method (enzymatic photometric test).
Results: The percentage of blood glucose is decreased levels was 16.75% and repaired kidney histopathology was 6.67% as a score mild damage category (1).
Conclusion: Black turmeric rhizome extract (Curcuma Caesia Roxb.) can reduce blood glucose levels and improve kidney function at a dose of 400 mg/kg BW.

Author Biographies

Zakiyyah Qurrotul Aini, Universitas Setia Budi

JL Letjen Sutoyo Mojosongo

Wiwin Herdwiani, Universitas Setia Budi

JL Letjen Sutoyo Mojosongo

Tri Wijayanti, Universitas Setia Budi

JL Letjen Sutoyo Mojosongo

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Published
2023-09-01
How to Cite
1.
Aini ZQ, Herdwiani W, Wijayanti T. Efektivitas rimpang kunyit hitam (curcuma caesia roxb.) terhadap penurunan glukosa darah dan perbaikan ginjal tikus diabetes nefropati. Media ilmu kesehatan [Internet]. 2023Sep.1 [cited 2024Jul.16];12(2):208-16. Available from: https://ejournal.unjaya.ac.id/index.php/mik/article/view/874