The relationship between antidiabetic drug interactions and clinical outcomes in type 2 diabetes mellitus patients

Authors

  • Sugiyono Sugiyono 3Prodi Farmasi (S-1), Fakultas Kesehatan, Universitas Jenderal Achmad Yani Yogyakarta https://orcid.org/0009-0005-8288-7489
  • Siwi Padmasari 3Prodi Farmasi (S-1), Fakultas Kesehatan, Universitas Jenderal Achmad Yani Yogyakarta
  • Shalahuddin Al Madury 3Prodi Farmasi (S-1), Fakultas Kesehatan, Universitas Jenderal Achmad Yani Yogyakarta

DOI:

https://doi.org/10.30989/mik.v14i1.1479

Keywords:

Antidiabetic, Clinical outcomes, Drug interactions

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that often requires combination therapy, increasing the risk of drug interactions due to polypharmacy, which can affect clinical outcomes.
Objective: To examine the relationship between the potential for drug interactions and clinical outcomes in hospitalized T2DM patients at PKU Muhammadiyah Gamping Hospital, Yogyakarta, from January 2022 to August 2023.
Methods: This study employed a non-experimental analytical method with a retrospective approach, involving 179 patients who met the inclusion criteria. Univariate analysis was used to describe patient characteristics, medication patterns, and Random Blood Glucose (RBG) levels, while bivariate analysis (Chi-Square test) assessed the relationship between the potential for drug interactions and clinical outcomes.
Results: The majority of T2DM patients were aged 41-59 years (50.28%), female (54.75%), and had comorbidities (91.62%). The most common treatment regimen was monotherapy with metformin (46.37%). Most patients received ≥5 medications (88.27%), and 81.56% had potential drug interactions. The predominant interaction mechanism was pharmacodynamic (86.21%) with moderate severity (89.72%). Chi-Square analysis yielded a p-value of 0.082 (p>0.05).
Conclusion: No significant relationship was found between the potential for antidiabetic drug interactions and clinical outcomes in patients

Author Biographies

Sugiyono Sugiyono, 3Prodi Farmasi (S-1), Fakultas Kesehatan, Universitas Jenderal Achmad Yani Yogyakarta

Jl. Brawijaya, Ringroad Barat, Ambarketawang, Gamping, Sleman Daerah Istimewa Yogyakarta, Indonesia

Siwi Padmasari, 3Prodi Farmasi (S-1), Fakultas Kesehatan, Universitas Jenderal Achmad Yani Yogyakarta

Jl. Brawijaya, Ringroad Barat, Ambarketawang, Gamping, Sleman Daerah Istimewa Yogyakarta, Indonesia.

Shalahuddin Al Madury, 3Prodi Farmasi (S-1), Fakultas Kesehatan, Universitas Jenderal Achmad Yani Yogyakarta

Jl. Brawijaya, Ringroad Barat, Ambarketawang, Gamping, Sleman Daerah Istimewa Yogyakarta, Indonesia.

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Published

2025-04-30

How to Cite

1.
Sugiyono S, Padmasari S, Al Madury S. The relationship between antidiabetic drug interactions and clinical outcomes in type 2 diabetes mellitus patients. Media ilmu kesehatan [Internet]. 2025 Apr. 30 [cited 2025 May 4];14(1):50-63. Available from: https://ejournal.unjaya.ac.id/index.php/mik/article/view/1479

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Vol. 14 No. 1 (2025): Media Ilmu Kesehatan

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