Overview of coagulation factors and platelet counts in patients with type 2 diabetes mellitus: a cross-sectional study

Authors

  • Maura Salsabila Alfitri Program Studi S1 Kedokteran, Fakultas Kedokteran Universitas Andalas
  • Eva Decroli Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil
  • Zelly Dia Rofinda Departemen Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil
  • Dinda Aprilia Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil
  • Dwi Yulia Departemen Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil
  • Mutia Lailani Departemen Fisiologi, Fakultas Kedokteran Universitas Andalas

DOI:

https://doi.org/10.30989/mik.v14i2.1314

Keywords:

Blood coagulation tests, clotting factors, diabetes complications, hematologic diseases, platelet function tests, type 2 diabetes mellitus

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a growing global health threat, where chronic hyperglycemia and insulin resistance can affect coagulation profiles.
Objective: This study aims to examine coagulation factor profiles and platelet counts in T2DM patients.
Methods: A descriptive cross-sectional observational study using data from prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), and platelet counts of T2DM patients admitted to the Internal Medicine Ward of Dr. M. Djamil General Hospital, Padang, in October 2023. Data analysis was performed descriptively using SPSS v26 software.
Results: Of the 39 patients analyzed, the distribution of characteristics showed a male predominance of 64.1%, with the largest age group being 45–59 years (48.7%). The most common complication associated with T2DM was chronic kidney disease, identified in 82.1% of the study population. Evaluation of hemostasis parameters showed that APTT was prolonged in 56.4% of patients. Conversely, PT (87.2%), INR (87.2%), and platelet count (66.7%) were within reference ranges.
Conclusion: This study found most coagulation parameters normal, but a relatively high proportion had prolonged APTT, underscoring the need for individualized coagulation monitoring in T2DM, especially with renal complications

Author Biographies

Maura Salsabila Alfitri, Program Studi S1 Kedokteran, Fakultas Kedokteran Universitas Andalas

Limau Manis, Kec. Pauh, Padang 25176, Indonesia.

Eva Decroli, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil

Padang, 25171, Indonesia.,

Zelly Dia Rofinda, Departemen Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil

Padang, 25171, Indonesia.

Dinda Aprilia, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil

Padang, 25171, Indonesia.

Dwi Yulia, Departemen Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran Universitas Andalas/ RSUP Dr. M. Djamil

Padang, 25171, Indonesia.

Mutia Lailani, Departemen Fisiologi, Fakultas Kedokteran Universitas Andalas

Limau Manis, Kec. Pauh, Padang 25176, Indonesia.

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Published

2025-08-30

How to Cite

1.
Alfitri MS, Decroli E, Rofinda ZD, Aprilia D, Yulia D, Lailani M. Overview of coagulation factors and platelet counts in patients with type 2 diabetes mellitus: a cross-sectional study. Media ilmu kesehatan [Internet]. 2025 Aug. 30 [cited 2025 Aug. 31];14(2):199-208. Available from: https://ejournal.unjaya.ac.id/index.php/mik/article/view/1314

Issue

Vol. 14 No. 2 (2025): Media Ilmu Kesehatan

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